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About InnoPen and Microneedling

InnoPen is the world's most advanced and safe microneedling device perfected by the pioneer of derma-needling technology, Clinical Resolution Laboratory, Inc. (CRL)

InnoPen microneedling is ideal for the non-surgical and non-ablative treatment of various skin conditions.

InnoPen is a medical precision tool with a unique, dual spring-loaded disposable needle cartridge (InnoTip) that uses an automated, vibrating stamp-like motion to cause micro-injury to the skin. The gentle fibroblast stimulation promotes the natural induction of collagen and elastin without the stress of pain and lengthy downtime associated with ablative treatments. Micro-channels, resulting from the needles piercing through the skin layers, will aid in infusing therapeutic serums for greater penetration and enhancement of overall efficacy.

InnoPen Helps

  • Intensify trans-dermal delivery for cosmetic, topical, photo aging, platelet-rich plasma (PRP) treatments
  • Diminish fine lines and wrinkles
  • Rejuvenate skin with comprehensive improvement of skin tone and texture
  • Minimize stretch marks
  • Restore youth by effectively tightening, lifting, and thickening the skin
  • Improve the appearance of scars (surgical, burns, acne vulgaris depressions)
  • Reduce pore size and increase absorption of cosmeceutical solutions
  • Deliver visible results painlessly and safely with little to no downtime
  • Cleanse face and neck thoroughly.


Product Specifications


  • Function: Microneedling Device
  • Input Power: 5V = 1A
  • InnoPen Dimensions: Height 5.4 in
  • InnoPen Weight: 97g w/Tip - 93g w/o Tip
  • Needle Depth: 0 to 2.0mm


  • Function: Microneedling Device
  • Innotip Dimensions: Height 1.7 in • Diameter 1 in
  • Innotip Weight: 4.12g
  • Needle Depth: 0 to 2.0mm

InnoPen Adaptor:

  • Product Reliability: 2000 hrs at 25°
  • Storage Temperature: 40° to 85°C
  • Storage Humidity: 0% to 90% RH
  • Operating Temperature: 0°C to 35°C

Adaptor Rating(s):

  • Input: AC 100 - 240V
  • Frequency: 50/60 Hz
  • Output: DC 5-6V


What is "Mesotherapy"?

The term uses the Greek "mesos" and "therapeia" to describe the methodology that applies non-surgical medicinal treatment techniques to the 'middle' layer of the skin. Mesotherapy describes a range of techniques that may be used for a wide range of disorders, but in the case of InnoPen, the method is cosmetic. The "mesotherapy effect" of MTS stimulates the skin to produce collagen without removing the top layer of the skin. MTS does not inject serums or solutions; it only permits a deeper infusion of topical applications (e.g., anti-aging serums), thereby increasing effectiveness.

What is InnoPen?

InnoPen is part of a family of "skin-friendly" products based on the "mesotherapy" concept. InnoPen doesn't burn your skin (IPL/laser), dissolve it (chemical peels), or rub and scrape it (dermabrasion). InnoPen gently stimulates your skin with 13 excellent "bristles" that encourage natural collagen production. Collagen is what your body produces to keep your skin healthy. The "mesotherapy effect" also dramatically increases penetration of therapeutic topical serums and other applications that contain growth factors, multi-peptides, vitamins, liposomes, herbs, and hair growth formulas (e.g., O2P, Propecia, Minoxidil). Clinical studies from Europe, the US, and South Korea have proven that InnoPen increases serum absorption by as much as 1,000 times.

Are there clinical studies to back up the claims of InnoPen?

Yes. Comparison clinical studies conducted by leading dermatological universities in South Korea have also shown that MTS microneedling devices are more effective in increasing the thickness of the skin than IPL and just as effective as ablative treatments (chemical peel, dermabrasion, laser resurfacing) and non-ablative machine-based treatments like CO2 laser, Fraxel, and Thermage. Additional studies on the mesotherapy concept have been conducted by other leading universities in Germany, South Africa, and Australia and by practitioners in the United States. Moreover, clinical acceptance of this method is multiplying in the US; the American Society for Aesthetic Plastic Surgery reports that mesotherapy grew 505% from 2005 to 2006 while other treatment methods have either subsided (e.g., Botox injections, -3%, dermabrasion, -28%) or flattened (chemical peel, 0%).

What areas of the body can InnoPen treat?

InnoPen can be used on all body parts: Face, neck, décolleté, arms, hands, legs, abdomen, and back.

Who is a likely candidate for InnoPen?

InnoPen can be used on all skin types and skin colors and can address many problems, such as acne scars, stretch marks, fine lines, and wrinkles. This allows for more versatility than lasers, chemical peels, or other common ablative skin treatments, which are sensitive to darker skin types.

What does a treatment with InnoPen feel like?

The feeling associated with the InnoPen is similar to light sandpaper moving across the skin. We strongly recommend using our Numb Master topical anesthetic before each treatment for added comfort. While some areas are more sensitive than others, the speed of the reciprocating needle tip reduces discomfort, while the applied treatment solution also makes the treatment more tolerable.

What is the downtime, and what side effects should I expect?

The total healing time depends on the severity of the damaged skin, the depth of the repair process required, and how aggressively the treatment is performed. Most patients have slight swelling, heat, and redness/pinkness (like a mild sunburn) for 2-3 days. Some patients may heal completely in 24 hours.

Do I have to use certain products with InnoPen?

Yes. CRL has made our entire product line safe before and after microneedling treatments. Using products without our unique formulations can result in burning, stinging, discomfort, excessive redness, and possible infection. Ask your skin care professional about what products are suitable for your needs.

Can I wear makeup immediately following an InnoPen procedure?

Depending on the area and type of treatment, patients typically can resume their regular makeup regimen 2-3 days after their InnoPen treatment.

Does InnoPen smooth acne scarring?

By inducing collagen and elastin production, InnoPen does something that no other treatment method can do–without removing the top layer of the skin. Within the first treatment with InnoPen™, patients notice diminished superficial acne scars. After the 3rd treatment, deeper acne scars will begin to fill in. By the 5th and 6th treatments, patients experience results similar to a deep chemical peel or laser resurfacing.

Can InnoPen help men?

Absolutely. Many men find InnoPen treatment less intimidating than the preparations required for other methods because it is a bit like getting a shave at a barber.

Can you use Microdermabrasion with InnoPen?

Yes. InnoPen is compatible with most other non-ablative treatment modalities. For instance, some patients may notice scaling on the skin as a result of the InnoPen in action. To start, you may use no more than a mild ablative wash to smooth out the scaling. After about the first six months, when InnoPen treatments are given ample time to thicken the skin, you may undergo microdermabrasion treatment to help exfoliate. Microdermabrasion will further stimulate collagen production and even out skin texture and tone.

Can InnoPen make hyperpigmentation less noticeable?

Yes. InnoPen Pro and MD models can help to inhibit hyperpigmentation. This is where collagen induction can easily aid the skin without irritating the epidermis. Several treatments from a specialist are required to even out skin tone and get rid of hyperpigmentation.

Do you see a difference after one InnoPen treatment?

Yes. Even the first treatment will show some enhancement. Fundamental differences are achieved with monthly clinical treatments. A patient will notice significant changes after the third treatment and weekly personal roller application. The total effect is achieved after six months.

Is there anyone who should not use InnoPen?

InnoPen should not be used in patients with Active Cold Sore (Herpes Simplex Virus) and Acne, Keloid Scars or Raised Scarring, History of Eczema, Psoriasis or other chronic conditions, Presence of Raised Moles, Warts or Raised Lesions on Treatment Area, New Scar Tissue/Wounds. Absolute Contraindications include Scleroderma, Active bacterial or fungal infection, and Pregnant or Nursing Women.

Microneedling is ideal for the non-surgical and non-ablative treatment of various skin conditions such as aging (wrinkles, stretching), scarring (acne, surgical), and hyperpigmentation.

Absolute Absorbency

MTS Roller causes micro-injuries to the skin to trigger the body's natural wound-healing response. The micro-injuries stimulate the release of cytokines and growth factors that lead to accelerated induction and remodeling of collagen and elastin. Hundreds of microchannels created by the MTS Roller serve as delivery conduits that aid in infusing therapeutic serums through the dermal layers to optimize clinical results. Clinical studies across the continents have shown that serum absorption increases by as much as 3,000 percent when applied with MTS Roller. Moreover, the studies have also demonstrated that treatment with MTS Roller is more consistent in increasing skin thickness than other resurfacing treatments.

Fast Recuperative Power

The gentle stimulation the MTS Roller provides is far more "skin friendly" and much less painful than many other invasive and more expensive skin treatments. Unlike chemical and energy-based ablations that destroy and damage the epidermis, MTS Roller leaves the entire epidermal barrier intact. The microchannels are closed within a matter of minutes to hours. This allows enough time for deeper penetration of solutions within the lower layers of the skin but is short enough to minimize complications and downtime to allow the patient to resume everyday routines quickly. MTS Roller eliminates commonly known adverse side effects and risks associated with chemical peeling, dermabrasion, and laser resurfacing. After microneedling with MTS Roller, the skin is thicker, healthier, and more responsive to additional treatments. MTS Roller models MR2 and MR3 are designed for personal care and are virtually painless. MR5, MR10, MR15, and MR20 are only clinical rollers for licensed professionals and should be used with topical anesthetic cream (i.e., Numb Master).


Skin Friendly

Ablative treatments like dermabrasion, chemical peels, and laser resurfacing do one thing: remove the protective epidermis to force the body to produce a new tissue layer. However, once the epidermis is removed, the lower levels of the skin are completely exposed and vulnerable to environmental contamination from dirt, dust, and bacteria. Specific risks must be accepted with these procedures: pain, long-term discomfort, long prevailing inflammation and redness, long healing period, extreme light-sensitivity for a month or more, possible irreversible pigment changes, and even additional scarring is a possibility.

Ablative treatments have their limits. Due to different skin structures on the neck, for instance, laser resurfacing may not be possible. Moreover, because these treatments leave the skin thinner, these procedures may age the skin. Microneedling is far more 'skin friendly' by doing much less damage, encouraging faster, longer-lasting positive effects. Since the skin can recuperate more quickly after a microneedling treatment – often hours after treatment – the patient may see noticeable results sooner!

Less Invasive, Less Expensive, More Effective With so many choices, how do you choose from one non-surgical skin treatment over the other? How do you know which is best for you? Here's an easy comparison of three non-surgical, minimally invasive techniques taking into consideration known side effects, downtime, expected results, and cost.

What Happens? All treatments have a common goal: injure the skin just enough to begin natural healing processes. Ablative treatments like chemical peels, dermabrasion, and laser skin resurfacing accomplish this task by removing the entire top layer of skin. Microdermabrasion is also ablative but is superficial and cannot treat deeper imperfections. New technologies like radio frequency and IPL are non-ablative (they do not remove the top layer) and have demonstrated effectiveness, but the equipment is costly; thus, treatments can be costly to the patient. Microneedling is unique because it produces similar results without expensive equipment and without removing skin layers; treatments are comparatively inexpensive and pose minimal risks.

Treatment Survey

1. Dermabrasion and Chemical Peels

Dermabrasion and Chemical Peels are popular ablative techniques. Dermabrasion requires the clinician to use a power-driven handheld machine with a rotating metal wheel and a diamond fraise or a wire brush to remove the top layers of the skin. Depending on the area submitted to the treatment, it can be performed using a general or a local anesthetic. Chemical peels use a mild acid solution to achieve the same effect. Both ablatives require great clinical artistry, skill, and experience to ensure successful outcomes.

2. Laser skin resurfacing

Laser skin resurfacing uses high-intensity light emissions to vaporize the top layers to remove scars or wrinkles. Like dermabrasion and chemical peels, laser resurfacing stimulates collagen and elastin production in the skin to make wrinkles and other imperfections less visible. Also, like other ablatives, laser resurfacing requires a great deal of clinical artistry, skill, and experience to ensure a positive outcome.

3. Non-Ablative Machine-based treatments

Non-Ablative Machine-based treatments include many recent innovations, many entirely new and costly. Radiofrequency treatments deliver high-energy influences to a large tissue area without epidermal injury. The underlying effect is the same as microwave cooking. IPL (intense pulse light) or 'Photorejuvenation' focuses broad spectrum light onto the skin to influence texture and pigmentation.

4. Microdermabrasion

Microdermabrasion is a milder peeling procedure (ablative), a gentle mechanical peel that uses a stream of crystals (or a diamond-tipped wand) and suction to exfoliate the skin gently. Home care microdermabrasion kits are readily available from many pharmacies and department stores.

5. Microneedling

Microneedling is a mesotherapeutic 'non-ablative' non-surgical procedure that facilitates the preservation of the top layer of skin while inducing the body to produce collagen and elastin. Treatment involves a roller (or an automated clinical device) with needles that range from a short length (0.2mm) to a lengthy size (2.0mm). A Clinician must administer the clinical version with a mild topical anesthetic.

DowntimeThe downtime required for various skin therapies depends on the depth of the injury caused to the skin. Microdermabrasion produces minimal downtime – a few hours of tingling and redness. But a deep chemical peel can keep you at home on painkillers for as much as two weeks.

Dermabrasion and laser resurfacing will leave the skin red and swollen for around ten days; total recovery can be up to three weeks.

Microneedling is truly non-ablative and produces little downtime – skin may be red and sensitive for about two to three hours after treatment.

Skin Treatment ComparisonMicroneedling with MTS topical products: Less Invasive, less expensive, and more effective

Risks And Side Effects There are great stories about inadequate care by professionals when performing dermabrasion, chemical peels, and laser resurfacing. Not only do these procedures require a great deal of training to master, but they also require some amount of artistry in judging how much of the skin to remove: too little, and the patient walks away with less than what they paid for; too much and there could be permanent damage like scarring or pigmentation changes. Moreover, these treatments may only suit people with lighter skin types.

Meanwhile, new machine-based treatments like radio frequency, IPL, and other non-ablatives do not exhibit many side effects, but the performance/artistry risks are the same. Microdermabrasion has the advantage of displaying fewer side effects and less risk because it is a less-invasive procedure. However, microdermabrasion has limited effectiveness in removing deeper acne scars, wrinkles, age spots, and stretch marks.

Microneedling has no common risks and offers all the advantages of the most invasive and expensive treatments. The needles can only go into the skin so far, so CRL offers six different models of our MTS Roller. The critical variable is for the practitioner to determine which rollers to use. Even if the provider goes too deep, the damage is minimal and not permanent.

In terms of delivering smoother skin and a longer-lasting effect, clinical studies have shown that the mesotherapeutic effect of microneedling at 0.5mm needle depth tends to outperform other ablative treatments (chemical peel, dermabrasion, laser resurfacing), as well as CO2 laser, Fraxel and IPL.